反应详情

温度

2.5 °C

Sodium bicarbonate (240 g) was added to a mixture of D-serine (100 g) and water (800 ml) at 0-5° C. Benzylchloroformate (50% solution in toluene)(480 ml) was added to the reaction mixture and stirred for 10 hours at 0-5° C. The organic and aqueous layers were separated and washed the aqueous layer with toluene. Aqueous layer pH was adjusted to 1.5 with hydrochloric acid and extract the reaction mixture in to ethyl acetate. Distilled off the solvent from the extracted reaction mixture under reduced pressure to get the title compound.

1. customThe organic and aqueous layers were separated
2. washwashed the aqueous layer with toluene
3. extractionextract the reaction mixture in to ethyl acetate
4. distillationDistilled off the solvent
5. customfrom the extracted reaction mixture under reduced pressure