反应详情

温度

17.5 °C

Sodium bicarbonate (60 g) was added to a mixture of D-serine (25 g) and water (375 ml) at 15-20° C. Benzylchloroformate (50% solution in toluene)(120 ml) was added slowly to the reaction mixture and stirred for 10 hours at 15-20° C. Filtered the reaction mixture and the filtrate was taken. The organic and aqueous layers were separated and washed the aqueous layer with methylene chloride. Aqueous layer pH was adjusted to 1.5 with hydrochloric acid. Stirred the reaction mixture for 90 minutes. Filtered the solid and washed with water. Dried the material to get the title compound.

1. filtrationFiltered the reaction mixture
2. customThe organic and aqueous layers were separated
3. washwashed the aqueous layer with methylene chloride
4. stirringStirred the reaction mixture for 90 minutes
5. filtrationFiltered the solid
6. washwashed with water
7. customDried the material