Hydrochloric Acid → HCID 178426095, compound

HRID 1401895Notes

Reaction equation

HRID 1401895 reaction equation
C([O:5][C:6](=[O:48])[C:7]1[CH:12]=[CH:11][C:10]([CH2:13][C@H:14]([C:32]2[CH:37]=[CH:36][C:35]([C@H:38]3[CH2:43][CH2:42][C@@H:41]([C:44]([CH3:47])([CH3:46])[CH3:45])[CH2:40][CH2:39]3)=[CH:34][CH:33]=2)[C:15](=[O:31])[NH:16][C:17]2[CH:22]=[CH:21][C:20]([C:23]3[CH:28]=[CH:27][C:26]([Cl:29])=[CH:25][C:24]=3[CH3:30])=[CH:19][CH:18]=2)=[CH:9][CH:8]=1)(C)(C)C.FC(F)(F)C(O)=O.Cl>ClCCl>[C:44]([C@@H:41]1[CH2:42][CH2:43][C@H:38]([C:35]2[CH:34]=[CH:33][C:32]([C@H:14]([C:15](=[O:31])[NH:16][C:17]3[CH:18]=[CH:19][C:20]([C:23]4[CH:28]=[CH:27][C:26]([Cl:29])=[CH:25][C:24]=4[CH3:30])=[CH:21][CH:22]=3)[CH2:13][C:10]3[CH:11]=[CH:12][C:7]([C:6]([OH:48])=[O:5])=[CH:8][CH:9]=3)=[CH:37][CH:36]=2)[CH2:39][CH2:40]1)([CH3:47])([CH3:46])[CH3:45]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 6422Trifluoroacetic acidHCID 178426096HCID 178426096, compound

Product 1

HCID 178426095HCID 178426095, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 431 mg of 4-[(R)-2-[4-(4-(cis)-tert-Butyl-cyclohexyl)-phenyl]-2-(4′-chlor-2′-methyl-biphenyl-4-ylcarbamoyl)-ethyl]-benzoic acid tert-butyl ester in dichloromethane (10 mL) was treated with trifluoroacetic acid (2 mL) and concentrated aqueous hydrochloric acid (1 mL). The resulting mixture was stirred for 16 h at room temperature. The organic phase was separated, washed with water and dried over magnesium sulfate. Concentration left a residue that was used without further purification.

Workup

  1. customThe organic phase was separated
  2. washwashed with water
  3. dry with materialdried over magnesium sulfate
  4. concentrationConcentration
  5. waitleft a residue that
  6. customwas used without further purification

Sources & evidence

ORD record
ord-48777270ee4a4c7e8b148ba8649b6c88
Source dataset
uspto-grants-2014_12
Patent number
US08907103B2

Reaction notes

Loading…