Water → 2-((Dimethylamino)methyl)-1-(3-methoxyphenyl)cyclohexanol

HRID 1402640Notes

Reaction equation

HRID 1402640 reaction equation
C(O)C(O)C.[CH3:6][N:7]([CH2:9][CH:10]1[C:15]([OH:24])([C:16]2[CH:21]=[C:20]([O:22][CH3:23])[CH:19]=[CH:18][CH:17]=2)[CH2:14][CH2:13][CH2:12][CH2:11]1)[CH3:8].Cl.O>C(O)C>[CH3:8][N:7]([CH2:9][CH:10]1[C:15]([OH:24])([C:16]2[CH:21]=[C:20]([O:22][CH3:23])[CH:19]=[CH:18][CH:17]=2)[CH2:14][CH2:13][CH2:12][CH2:11]1)[CH3:6]

Participants

5

Reactant 3

HCID 962WaterHCID 1030Propylene GlycolHCID 9971980Cyclohexanol, 2-((dimethylamino)methyl)-1-(3-methoxyphenyl)-, hydrochloride (1:1)2×

Product 1

HCID 55232-((Dimethylamino)methyl)-1-(3-methoxyphenyl)cyclohexanol

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

10 grams of the above formulation were prepared as follows: 0.5 g soy phospholipid was dissolved in 1.5 grams ethanol and 2 grams propylene glycol was added to this solution followed by addition of Vitamin E and mixing for 5 minutes. Then, 90 mg Tramadol HCl was added to this mixture. Water was added slowly with constant stirring by a Heidolph overhead stirrer. The composition is stirred for additional 10 minutes. The final composition contains 9 mg/g Tramadol HCl.

Workup

  1. custom10 grams of the above formulation were prepared
  2. additionmixing for 5 minutes
  3. stirringThe composition is stirred for additional 10 minutes

Sources & evidence

ORD record
ord-3958ead31632441c91e61d696c9d87c6
Source dataset
uspto-grants-2014_12
Patent number
US08911751B2

Reaction notes

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