1,2-Dibromoethane → HCID 117734590, compound

HRID 1402651Notes

Reaction equation

HRID 1402651 reaction equation
[CH2:1]([O:3][P:4]([CH2:13][C:14]#[N:15])([C:6]1[CH:11]=[CH:10][C:9]([F:12])=[CH:8][CH:7]=1)=[O:5])[CH3:2].C(=O)([O-])[O-].[K+].[K+].Br[CH2:23][CH2:24]Br>CS(C)=O>[CH2:1]([O:3][P:4]([C:13]1([C:14]#[N:15])[CH2:24][CH2:23]1)([C:6]1[CH:11]=[CH:10][C:9]([F:12])=[CH:8][CH:7]=1)=[O:5])[CH3:2]

Participants

5

Reactant 3

HCID 78391,2-DibromoethaneHCID 11430Potassium CarbonateHCID 117734592HCID 117734592, compound

Product 1

HCID 117734590HCID 117734590, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

0.470 g of ethyl(cyanomethyl)(4-fluorophenyl)phosphinate was initially charged in 20 ml of DMSO, and 0.572 g (4.138 mmol) of potassium carbonate and then 0.388 g of 1,2-dibromoethane were added. The mixture was stirred at room temperature for 4 h and then at 50° C. for 2 h. The reaction mixture was concentrated, taken up in dichloromethane and washed with H2O.

Workup

  1. waitat 50° C. for 2 h
  2. concentrationThe reaction mixture was concentrated
  3. washwashed with H2O

Sources & evidence

ORD record
ord-ff75b03421fb44f1971b536e803eeae7
Source dataset
uspto-grants-2014_12
Patent number
US08912124B2

Reaction notes

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