2-Amino-5-chlorophenol → HCID 66759757, compound

HRID 1402836Notes

Reaction equation

HRID 1402836 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:14][C:13](=[O:15])[O:12][C:10](=[O:11])[CH2:9]2)=[CH:4][CH:3]=1.[Cl:16][C:17]1[CH:23]=[CH:22][C:20]([NH2:21])=[C:19]([OH:24])[CH:18]=1>ClCCl>[OH:24][C:19]1[CH:18]=[C:17]([Cl:16])[CH:23]=[CH:22][C:20]=1[NH:21][C:13](=[O:15])[CH2:14][CH:8]([C:5]1[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=1)[CH2:9][C:10]([OH:12])=[O:11]

Participants

4

Reactant 2

HCID 915912-Amino-5-chlorophenolHCID 1046394-(4-Chlorophenyl)dihydro-2H-pyran-2,6(3H)-dione

Product 1

HCID 66759757HCID 66759757, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Prepared by refluxing an equimolar mixture of 3-(4-chlorophenyl)glutaric anhydride and commercial 4-chloro-2-hydroxyaniline in dichloromethane for 0.5 h. After cooling to rt the precipitated product is isolated by suction filtration, washed, and dried to provide 90% of N-(2-hydroxy-4-chlorophenyl)-3-(4-chlorophenyl)glutaramic acid as light red crystals.

Workup

  1. customPrepared
  2. temperatureby refluxing
  3. customis isolated by suction filtration
  4. washwashed
  5. customdried

Sources & evidence

ORD record
ord-48acf899e6bd4bca995364d38e190ca2
Source dataset
uspto-grants-2014_12
Patent number
US08912186B2

Reaction notes

Loading…