p-Bromoacetophenone → 4′-Bromo-4-chlorochalcone

HRID 1402944Notes

Reaction equation

HRID 1402944 reaction equation
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=O)=[CH:4][CH:3]=1.[CH3:10][C:11]([C:13]1[CH:18]=[CH:17][C:16]([Br:19])=[CH:15][CH:14]=1)=[O:12]>>[Br:19][C:16]1[CH:17]=[CH:18][C:13]([C:11](=[O:12])[CH:10]=[CH:6][C:5]2[CH:8]=[CH:9][C:2]([Cl:1])=[CH:3][CH:4]=2)=[CH:14][CH:15]=1

Participants

3

Reactant 2

HCID 7466p-BromoacetophenoneHCID 77264-Chlorobenzaldehyde

Product 1

HCID 227894′-Bromo-4-chlorochalcone

Procedure

By a procedure similar to that of example 1.59.1, starting from 4-chlorobenzaldehyde and 4-bromoacetophenone, 1-(4-bromophenyl)-3-(4-chlorophenyl)prop-2-en-1-one was obtained as yellowish solid.

Sources & evidence

ORD record
ord-4f03c48e7f704c44b8f89cf08a4c96a1
Source dataset
uspto-grants-2014_12
Patent number
US08912186B2

Reaction notes

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