Hydrochloric Acid → HCID 66760919, compound

HRID 1402964Notes

Reaction equation

HRID 1402964 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH:22]([C:27]([O:29][CH3:30])=[O:28])[C:23]([O:25][CH3:26])=[O:24])[CH2:9][C:10]([C:12]2[CH:17]=[CH:16][C:15]([O:18]COC)=[CH:14][CH:13]=2)=[O:11])=[CH:4][CH:3]=1.Cl>CO>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]([CH:22]([C:27]([O:29][CH3:30])=[O:28])[C:23]([O:25][CH3:26])=[O:24])[CH2:9][C:10]([C:12]2[CH:17]=[CH:16][C:15]([OH:18])=[CH:14][CH:13]=2)=[O:11])=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66760462HCID 66760462, compound

Product 1

HCID 66760919HCID 66760919, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of dimethyl 2-(1-(4-chlorophenyl)-3-(4-(methoxymethoxy)phenyl)-3-oxopropyl)malonate (0.3 g) in methanol (10 ml) was treated with 10% HCl (2 ml) and the resulting mixture was refluxed for 2 h. After cooling to room temperature the solvent was removed, the residue was extracted with ethyl acetate, and dried (magnesium sulphate). After concentration the crude (0.3 g yellow oil) was used for the next step without further purification.

Workup

  1. temperaturethe resulting mixture was refluxed for 2 h
  2. customwas removed
  3. extractionthe residue was extracted with ethyl acetate
  4. dry with materialdried (magnesium sulphate)
  5. concentrationAfter concentration the crude (0.3 g yellow oil)
  6. customwas used for the next step without further purification

Sources & evidence

ORD record
ord-504b1724802e427ba20512a052438344
Source dataset
uspto-grants-2014_12
Patent number
US08912186B2

Reaction notes

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