反应详情

温度

90 °C

To a solution of methyl 3-chloro-2-oxo-1,2-dihydroquinoxaline-6-carboxylate (500 mg, crude) in DMSO (6 mL) was added DIEA (543 mg, 4.20 mmol) and azepane (208 mg, 2.10 mmol). The solution was stirred overnight at 90° C. Then the reaction was quenched by the addition of water (50 mL), extracted with ethyl acetate (5×20 mL) and the organic layers were concentrated under vacuum to give a residue, which was purified by a silica gel column with 1%-5% ethyl acetate in petroleum ether to afford methyl 3-(azepan-1-yl)-2-oxo-1,2-dihydroquinoxaline-6-carboxylate as a yellow solid (165 mg).

1. customThen the reaction was quenched by the addition of water (50 mL)
2. extractionextracted with ethyl acetate (5×20 mL)
3. concentrationthe organic layers were concentrated under vacuum
4. customto give a residue, which
5. customwas purified by a silica gel column with 1%-5% ethyl acetate in petroleum ether