2-Mercaptoethanol → HCID 43392529, compound

HRID 1403677Notes

Reaction equation

HRID 1403677 reaction equation
[SH:1][CH2:2][CH2:3][OH:4].CCN(C(C)C)C(C)C.Br[CH:15]1[CH2:19][CH2:18][O:17][C:16]1=[O:20]>C1COCC1>[OH:4][CH2:3][CH2:2][S:1][CH:15]1[CH2:19][CH2:18][O:17][C:16]1=[O:20]

Participants

5

Reactant 3

HCID 15672-MercaptoethanolHCID 81531DiisopropylethylamineHCID 954632(3H)-Furanone, 3-bromodihydro-

Product 1

HCID 43392529HCID 43392529, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 2-mercapto-ethanol (2560 μmol) in THF (4 ml) were added DIEA (1.1 eq) and 3-bromo-dihydro-furan-2-one (1 eq). The reaction mixture was stirred at RT for 4 hours. The precipitate was filtered and the solvent was removed under reduced pressure.

Workup

  1. filtrationThe precipitate was filtered
  2. customthe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-0a48253ed4314febb7e7b6a3a4581f63
Source dataset
uspto-grants-2014_12
Patent number
US08912209B2

Reaction notes

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