Triethylamine → HCID 58303898, compound

HRID 1404128Notes

Reaction equation

HRID 1404128 reaction equation
Cl[C:2]1[CH:3]=[C:4]([F:20])[C:5]([O:17][CH2:18][CH3:19])=[C:6]2[C:10]=1[N:9]([CH3:11])[CH:8]=[C:7]2[CH2:12][C:13]([O:15][CH3:16])=[O:14].CCN(CC)CC>CO.[Pd]>[CH2:18]([O:17][C:5]1[C:4]([F:20])=[CH:3][CH:2]=[C:10]2[C:6]=1[C:7]([CH2:12][C:13]([O:15][CH3:16])=[O:14])=[CH:8][N:9]2[CH3:11])[CH3:19]

Participants

5

Reactant 2

HCID 8471TriethylamineHCID 58303914HCID 58303914, compound

Product 1

HCID 58303898HCID 58303898, compoundYield 92%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of 30-11 (1.4 g, 4.7 mmol), Pd/C (280 mg, 20%) and Et3N (1.42 g, 14.1 mmol) in MeOH (20 mL) was stirred under hydrogen atmosphere at room temperature overnight. The mixture was filtered and the filtrate was concentrated to afford 30-12 (1 g, 92%) as a yellow solid. LRMS: calc 265.1 and found: 266.1 [M+1].

Workup

  1. filtrationThe mixture was filtered
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-e02f3dd8e22d465ab9dc3c98549b4f28
Source dataset
uspto-grants-2014_12
Patent number
US08912220B2

Reaction notes

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