反应详情

温度

50 °C

To the reaction mixture of (4-{4-[2-(3-methoxyphenylamino)-thiazol-4-yl]-phenyl}-cyclohexyl)-acetic acid ethyl ester from step B is added LiOH (10% solution, 1 mL). It is then heated at 50° C. for 18 h. The mixture is then acidified with HCl solution (1 N) to pH=5. The resulting solid is filtered and dried under high vacuum to give the title compound (26.8 mg) as a solid; 1H NMR (400 MHz, DMSO-d6) δ ppm 0.96-1.07 (m, 2 H) 1.31-1.43 (m, 2 H) 1.50-1.52 (m, 1 H) 1.58-1.64 (m, 1 H) 1.71 (d, J=9.60 Hz, 4 H) 2.03 (d, J=6.57 Hz, 2 H) 2.27 (br. s., 1 H) 3.67 (s, 3 H) 6.43 (dd, J=7.83, 1.77 Hz, 1 H) 7.03 (dd, J=7.20, 0.88 Hz, 1 H) 7.09-7.20 (m, 4 H) 7.44 (br. s., 1 H) 7.70 (d, J=8.08 Hz, 2 H) 10.13 (br. s., 1 H); MS (M+H)+=423.2.

1. filtrationThe resulting solid is filtered
2. customdried under high vacuum