Phenethyl bromide → 1-(1-phenylethyl)pyrrolidin-2-one

HRID 1404432Notes

Reaction equation

HRID 1404432 reaction equation
[NH:1]1[CH2:5][CH2:4][CH2:3][C:2]1=[O:6].Br[CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.[H-].[Na+]>CN(C)C=O>[C:10]1([CH:9]([N:1]2[CH2:5][CH2:4][CH2:3][C:2]2=[O:6])[CH3:8])[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

Participants

5

Reactant 3

HCID 7666Phenethyl bromideHCID 120252-PyrrolidoneHCID 24758Sodium hydride

Product 1

HCID 38151651-(1-phenylethyl)pyrrolidin-2-one

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

1-Phenylethyl-2-pyrrolidone is prepared from 2-pyrrolidone and 2-bromoethylbenzene in N,N-dimethylformamide in the presence of sodium hydride (M. Matsukawa et al. NeuroToxicology 2004, 25, 293-302).

Sources & evidence

ORD record
ord-b344a97928bf47959e57c303cf4b244b
Source dataset
uspto-grants-2014_12
Patent number
US08912329B2

Reaction notes

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