反应详情

1-(2,6-dichloro-3-fluorophenyl)ethanol (5.2 g, 24.9 mmol), methanesulfonyl chloride (6.3 g, 55 mmol, 2.2 eq), and triethylamine (6.1 g) were stirred in 50 ml of DCM and 12 ml of DMF at room temperature overnight. Water and DCM were added, and the layers were separated. The aqueous layer was extracted with DCM. The combined organic layers were dried, evaporated and chromatographed (EtOAc/Hexanes 1:10) to give an oil, 5.11 g, in 71% yield.

1. customat room temperature
2. customovernight
3. customthe layers were separated
4. extractionThe aqueous layer was extracted with DCM
5. customThe combined organic layers were dried
6. customevaporated
7. customchromatographed (EtOAc/Hexanes 1:10)
8. customto give an oil, 5.11 g