反应详情

tert-butyl 4-(4-{6-[(E)-2-(dimethylamino)ethenyl]-5-nitropyridin-3-yl}-1H-pyrazol-1-yl)piperidine-1-carboxylate (366 mg, 0.81 mmol) and SnCl2.2H2O (966 mg, 4.26 mmol, 5.0 eq) in 3 ml of EtOAc were stirred at r.t. for 2 hours. EtOAc and water were added and layers were separated. The aqueous layer was extracted with EtOAc, washed with sat. NH4Cl and brine. After evaporation, the crude product was chromatographed (Mesh/DCM 1:20) to give a yellow solid, 170 mg, in 54% yield.

1. customlayers were separated
2. extractionThe aqueous layer was extracted with EtOAc
3. washwashed with sat. NH4Cl and brine
4. customAfter evaporation
5. customthe crude product was chromatographed (Mesh/DCM 1:20)
6. customto give a yellow solid, 170 mg