Hydrochloric Acid → HCID 178526506, compound

HRID 1404906Notes

Reaction equation

HRID 1404906 reaction equation
F[C:2]1[CH:8]=[CH:7][C:6]([N+:9]([O-:11])=[O:10])=[CH:5][C:3]=1[NH2:4].[C:12](=[S:17])(OCC)[S-:13].[K+].Cl>CN(C=O)C.O>[N+:9]([C:6]1[CH:7]=[CH:8][C:2]2[S:13][C:12]([SH:17])=[N:4][C:3]=2[CH:5]=1)([O-:11])=[O:10]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 677852-Fluoro-5-nitroanilineHCID 2735045Potassium ethylxanthate

Product 1

HCID 178526506HCID 178526506, compoundYield 94%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Conditions

Temperature
110 °C

Procedure

A mixture of 2-fluoro-5-nitro aniline (11, 1.00 g, 6.40 mmol) and potassium O-ethyl dithiocarbonate (1.53 g, 9.60 mmol) in DMF (15 mL) was heated overnight at 110-110° C. under N2. After cooling, the reaction mixture was diluted with water and acidified with 1N HCl. The precipitate was collected by filtration, washed with water, and dried under vacuum to yield compound 12 (1.27 g, 94%).

Workup

  1. temperatureAfter cooling
  2. filtrationThe precipitate was collected by filtration
  3. washwashed with water
  4. customdried under vacuum

Sources & evidence

ORD record
ord-6ec299a0bdb04a6bac73b0fee7a93ba7
Source dataset
uspto-grants-2014_12
Patent number
US08916550B2

Reaction notes

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