Potassium Carbonate → HCID 58513513, compound

HRID 1405025Notes

Reaction equation

HRID 1405025 reaction equation
[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[C:16]([C:17]#[C:18][Si](C)(C)C)=[C:15]([CH3:23])[N:14]=[C:13]([NH2:24])[N:12]=2)=[CH:7][CH:6]=1)(=[O:4])=[O:3].C(=O)([O-])[O-].[K+].[K+]>CO>[C:17]([C:16]1[C:11]([C:8]2[CH:9]=[CH:10][C:5]([S:2]([CH3:1])(=[O:4])=[O:3])=[CH:6][CH:7]=2)=[N:12][C:13]([NH2:24])=[N:14][C:15]=1[CH3:23])#[CH:18]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 58513523HCID 58513523, compound

Product 1

HCID 58513513HCID 58513513, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
0 °C

Procedure

The title compound is synthesized according to general procedure GP3 starting from 2.7 g (6.0 mmol) 4-(4-methanesulfonyl-phenyl)-6-methyl-5-trimethylsilanylethynyl-pyrimidin-2-ylamine (A-36) and 415 mg (3.0 mmol) potassium carbonate in 40 mL MeOH. After stirring for 2 h at 0° C. the precipitated product is filtered off and dried over night at 40° C. The product is treated with water, filtered off and dried again. Yield: 1.8 g (83%).

Workup

  1. filtrationis filtered off
  2. customdried over night at 40° C
  3. additionThe product is treated with water
  4. filtrationfiltered off
  5. customdried again

Sources & evidence

ORD record
ord-a663ca573cc74792bb5629653b75224c
Source dataset
uspto-grants-2014_12
Patent number
US08916548B2

Reaction notes

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