HCID 58513342, compound → HCID 58513336, compound

HRID 1405040Notes

Reaction equation

HRID 1405040 reaction equation
C[O:2][C:3](=[O:29])[C:4]1[CH:9]=[CH:8][C:7]([C:10]2[C:15]([C:16]#[C:17][C:18]3[CH:19]=[N:20][C:21]([CH3:24])=[CH:22][CH:23]=3)=[C:14]([CH2:25][CH3:26])[N:13]=[C:12]([NH2:27])[N:11]=2)=[CH:6][C:5]=1[F:28]>C1COCC1>[NH2:27][C:12]1[N:11]=[C:10]([C:7]2[CH:8]=[CH:9][C:4]([C:3]([OH:29])=[O:2])=[C:5]([F:28])[CH:6]=2)[C:15]([C:16]#[C:17][C:18]2[CH:19]=[N:20][C:21]([CH3:24])=[CH:22][CH:23]=2)=[C:14]([CH2:25][CH3:26])[N:13]=1

Participants

3

Reactant 1

HCID 58513342HCID 58513342, compound

Product 1

HCID 58513336HCID 58513336, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The title compound is synthesized according to general procedure GP8 starting from 130 mg (0.47 mmol) 4-[2-amino-6-ethyl-5-(6-methyl-pyridin-3-ylethynyl)-pyrimidin-4-yl]-2-fluoro-benzoic acid methyl ester using 470 μL (0.47 mmol) 1 N NaOH in 3 mL THF. The product precipitates from the reaction mixture and is isolated by filtration.

Workup

  1. customThe product precipitates from the reaction mixture
  2. customis isolated by filtration

Sources & evidence

ORD record
ord-9b62e3e259204349b010dad5ac04e1f8
Source dataset
uspto-grants-2014_12
Patent number
US08916548B2

Reaction notes

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