HCID 67004025, compound → HCID 67004490, compound

HRID 1405045Notes

Reaction equation

HRID 1405045 reaction equation
C[O:2][C:3](=[O:30])[C:4]1[CH:9]=[CH:8][C:7]([C:10]2[C:15]([C:16]#[C:17][C:18]3[CH:19]=[N:20][C:21]([NH:24][CH3:25])=[CH:22][CH:23]=3)=[C:14]([CH2:26][CH3:27])[N:13]=[C:12]([NH2:28])[N:11]=2)=[CH:6][C:5]=1[F:29]>C1COCC1>[NH2:28][C:12]1[N:11]=[C:10]([C:7]2[CH:8]=[CH:9][C:4]([C:3]([OH:30])=[O:2])=[C:5]([F:29])[CH:6]=2)[C:15]([C:16]#[C:17][C:18]2[CH:19]=[N:20][C:21]([NH:24][CH3:25])=[CH:22][CH:23]=2)=[C:14]([CH2:26][CH3:27])[N:13]=1

Participants

3

Reactant 1

HCID 67004025HCID 67004025, compound

Product 1

HCID 67004490HCID 67004490, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The title compound is synthesized according to general procedure GP8 starting from 238 mg (0.59 mmol) 4-[2-amino-6-ethyl-5-(6-methylamino-pyridin-3-ylethynyl)-pyrimidin-4-yl]-2-fluoro-benzoic acid methyl ester using 0.88 mL (0.88 mmol) 1 N NaOH in 3 mL THF.

Sources & evidence

ORD record
ord-fa602962baf845868bde487f8b6cebc2
Source dataset
uspto-grants-2014_12
Patent number
US08916548B2

Reaction notes

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