Lithium Hydroxide → HCID 58513126, compound

HRID 1405055Notes

Reaction equation

HRID 1405055 reaction equation
C([O:3][C:4]([CH:6]1[CH2:11][CH2:10][N:9]([C:12]2[C:17]([C:18]#[C:19][C:20]3[CH:21]=[N:22][C:23]([NH2:26])=[CH:24][CH:25]=3)=[C:16]([CH3:27])[N:15]=[C:14]([NH2:28])[N:13]=2)[CH2:8][CH2:7]1)=[O:5])C.[Li+].[OH-]>C1COCC1.O>[NH2:28][C:14]1[N:13]=[C:12]([N:9]2[CH2:8][CH2:7][CH:6]([C:4]([OH:5])=[O:3])[CH2:11][CH2:10]2)[C:17]([C:18]#[C:19][C:20]2[CH:21]=[N:22][C:23]([NH2:26])=[CH:24][CH:25]=2)=[C:16]([CH3:27])[N:15]=1

Participants

5

Reactant 2

HCID 3939Lithium HydroxideHCID 58513105HCID 58513105, compound

Product 1

HCID 58513126HCID 58513126, compoundYield 83.3%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

The title compound is synthesized according to general procedure GP8 starting from 1.0 g (2.63 mmol) 1-[2-amino-5-(6-amino-pyridin-3-ylethynyl)-6-methyl-pyrimidin-4-yl]-piperidine-4-carboxylic acid ethyl ester and 126 mg (5.26 mmol) LiOH in 80 mL THF and 20 ml water. Yielding 772 mg (2.19 mmol) of the desired product.

Workup

  1. customThe title compound is synthesized

Sources & evidence

ORD record
ord-4fad23eac2e441ba9bf649cbe3f9849d
Source dataset
uspto-grants-2014_12
Patent number
US08916548B2

Reaction notes

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