反应详情

To a solution of 2-(1H-indazol-5-yl)-3-[methyl(propan-2-yl)amino]quinoxaline-6-carboxylic acid (200 mg, 0.55 mmol) in dichloromethane (30 ml) was added triethylamine (210 mg, 2.08 mmol), 2-methylpropan-2-amine (121 mg, 1.65 mmol), and T3P (396 mg, 1.25 mmol), and the resulting mixture was stirred for 1 h at room temperature. The solution was diluted with water (150 ml), extracted with dichloromethane (3×50 ml), dried over anhydrous magnesium, and concentrated in vacuo to get N-tert-butyl-2-(1H-indazol-5-yl)-3-[methyl(propan-2-yl)amino]quinoxaline-6-carboxamide as a yellow solid (311 mg, crude).

1. extractionextracted with dichloromethane (3×50 ml)
2. dry with materialdried over anhydrous magnesium
3. concentrationconcentrated in vacuo