Ethanesulfonylchloride, 2-chloro- → HCID 66748912, compound

HRID 1405907Notes

Reaction equation

HRID 1405907 reaction equation
Cl[CH2:2][CH2:3][S:4](Cl)(=[O:6])=[O:5].[H-].[Na+].[CH:10](/[C:18]1[CH:23]=[CH:22][C:21]([C:24]2[C:25]([NH2:30])=[N:26][CH:27]=[CH:28][CH:29]=2)=[CH:20][CH:19]=1)=[CH:11]\[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>C1COCC1>[C:12]1(/[CH:11]=[CH:10]/[C:18]2[CH:23]=[CH:22][C:21]([C:24]3[C:25]4=[N:30][S:4](=[O:6])(=[O:5])[CH2:3][CH2:2][N:26]4[CH:27]=[CH:28][CH:29]=3)=[CH:20][CH:19]=2)[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1

Participants

5

Reactant 3

HCID 15385Ethanesulfonylchloride, 2-chloro-HCID 24758Sodium hydrideHCID 66748647HCID 66748647, compound

Product 1

HCID 66748912HCID 66748912, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Conditions

Temperature
0 °C

Procedure

2-Chloroethanesulfonyl chloride (0.410 mL) was added to a mixture of NaH (60%, 390 mg) in THF (dry) (8 mL) at 0° C. under nitrogen flow. The mixture was stirred at 0° C. for 5 min. The mixture of (E)-3-(4-styrylphenyl)pyridin-2-amine (531 mg) in THF (dry) (20 mL) was added dropwise and the mixture was stirred at room temperature under atmosphere overnight. The mixture was quenched with water at 0° C., and water, EtOAc and THF were added. The insoluble material was collected by filtration and crystallized from DMSO-EtOH to give the title compound (340 mg) as slightly pale yellow crystals.

Workup

  1. additionwas added dropwise
  2. stirringthe mixture was stirred at room temperature under atmosphere overnight
  3. customThe mixture was quenched with water at 0° C.
  4. additionwater, EtOAc and THF were added
  5. filtrationThe insoluble material was collected by filtration
  6. customcrystallized from DMSO-EtOH

Sources & evidence

ORD record
ord-4f03db2c355048219c98941aee91dc36
Source dataset
uspto-grants-2014_12
Patent number
US08916551B2

Reaction notes

Loading…