Hydrochloric Acid → HCID 66748128, compound

HRID 1405915Notes

Reaction equation

HRID 1405915 reaction equation
O1[C:5]2([CH2:10][CH2:9][CH:8]([O:11][C:12]3[CH:17]=[CH:16][C:15]([C:18]4[C:23]5=[N:24][S:25](=[O:29])(=[O:28])[CH2:26][CH2:27][N:22]5[CH:21]=[CH:20][CH:19]=4)=[CH:14][CH:13]=3)[CH2:7][CH2:6]2)[O:4]CC1.Cl.[OH-].[Na+]>C1COCC1>[O:29]=[S:25]1(=[O:28])[CH2:26][CH2:27][N:22]2[CH:21]=[CH:20][CH:19]=[C:18]([C:15]3[CH:14]=[CH:13][C:12]([O:11][CH:8]4[CH2:9][CH2:10][C:5](=[O:4])[CH2:6][CH2:7]4)=[CH:17][CH:16]=3)[C:23]2=[N:24]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 66824180HCID 66824180, compound

Product 1

HCID 66748128HCID 66748128, compoundYield 93.8%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A mixture of 9-[4-(1,4-dioxaspiro[4.5]dec-8-yloxy)phenyl]-3,4-dihydropyrido[2,1-c][1,2,4]thiadiazine 2,2-dioxide (130 mg), 1M hydrochloric acid (15 mL) and dehydrated THF (15 mL) was stirred at room temperature for 8 hr. The reaction mixture was neutralized with 1M aqueous sodium hydroxide solution, and extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over magnesium sulfate, and concentrated under reduced pressure. The residue was washed with diethyl ether to give the title compound (109 mg) as a pale-yellow solid.

Workup

  1. extractionextracted with ethyl acetate
  2. washThe organic layer was washed with saturated brine
  3. dry with materialdried over magnesium sulfate
  4. concentrationconcentrated under reduced pressure
  5. washThe residue was washed with diethyl ether

Sources & evidence

ORD record
ord-e429c9e2a462443981843c5e17150f58
Source dataset
uspto-grants-2014_12
Patent number
US08916551B2

Reaction notes

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