反应详情

温度

100 °C

To 9-bromo-3,4-dihydropyrido[2,1-c][1,2,4]thiadiazine 2,2-dioxide (26 mg) were added a solution of 2,4-dichlorophenylboronic acid (38 mg) in ethanol (0.5 mL), toluene (0.5 mL), tetrakis(triphenylphosphine)palladium(0) (11 mg) and cesium carbonate (98 mg), and the mixture was stirred at 100° C. overnight. To the reaction solution were added saturated aqueous sodium hydrogen carbonate solution (1 mL) and ethyl acetate (3 mL) and the mixture was stirred. The organic layer was passed through a phase separation filter, and the solvent was evaporated from the separated solution by an air blowing apparatus. The residue was purified by HPLC (C18, mobile phase:acetonitrile/10 mM aqueous ammonium acetate solution) to give the title compound (20.7 mg).

1. stirringthe mixture was stirred
2. customThe organic layer was passed through a phase separation
3. filtrationfilter
4. customthe solvent was evaporated from the separated solution by an air
5. customThe residue was purified by HPLC (C18, mobile phase:acetonitrile/10 mM aqueous ammonium acetate solution)