反应详情

To a solution of 4-methoxy-5-(2-methoxyethoxy)-2-nitrobenzonitrile (1.5 g) in anhydrous DCM (30 mL) was added anhydrous AlCl3 (6 g) at 0° C. The resulting mixture was heated to reflux for 1 h. After reaction finished, the mixture was diluted with 1N aqueous HCl (50 mL) and exacted with EA (3×50 mL). The combined organic layer was dried over Na2SO4, concentrated under reduced pressure, and purification by silica chromatography to give 0.8 g of 4-hydroxy-5-(2-methoxyethoxy)-2-nitrobenzonitrile.

1. temperatureThe resulting mixture was heated
2. temperatureto reflux for 1 h
3. customAfter reaction
4. dry with materialThe combined organic layer was dried over Na2SO4
5. concentrationconcentrated under reduced pressure, and purification by silica chromatography