Hydrochloric Acid → HCID 86701837, compound

HRID 1406022Notes

Reaction equation

HRID 1406022 reaction equation
[CH2:1]([C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([CH2:9][CH3:10])[C:4]=1[NH:11][C:12]([C:14]1[C:18]2[CH2:19][CH2:20][CH2:21][C:22]3[C:23](=[N:24][C:25]([NH:28][C:29]4[CH:34]=[CH:33][C:32]([N:35]5[CH2:40][CH2:39][N:38]([CH3:41])[CH2:37][CH2:36]5)=[CH:31][C:30]=4[O:42][CH3:43])=[N:26][CH:27]=3)[C:17]=2[N:16]([CH2:44][CH2:45][O:46]C2CCCCO2)[N:15]=1)=[O:13])[CH3:2].[ClH:53]>CO.O1CCOCC1>[ClH:53].[CH2:1]([C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([CH2:9][CH3:10])[C:4]=1[NH:11][C:12]([C:14]1[C:18]2[CH2:19][CH2:20][CH2:21][C:22]3[C:23](=[N:24][C:25]([NH:28][C:29]4[CH:34]=[CH:33][C:32]([N:35]5[CH2:36][CH2:37][N:38]([CH3:41])[CH2:39][CH2:40]5)=[CH:31][C:30]=4[O:42][CH3:43])=[N:26][CH:27]=3)[C:17]=2[N:16]([CH2:44][CH2:45][OH:46])[N:15]=1)=[O:13])[CH3:2]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 60151776HCID 60151776, compound

Product 1

HCID 86701837HCID 86701837, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of N-(2,6-diethylphenyl)-9-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}-1-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-1,4,5,6-tetrahydropyrazolo[4′,3′:6,7]cyclohepta[1,2-d]pyrimidine-3-carboxamide (0.040 g, 0.056 mmol) in MeOH (0.6 mL), 4M HCl in dioxane (0.010 mL) was added. The mixture was stirred at room temperature for 1 h. The organic solvent was evaporated to dryness to give the title compound in quantitative yield.

Workup

  1. customThe organic solvent was evaporated to dryness

Sources & evidence

ORD record
ord-67650075068f4a9c8c5867ee5552dc66
Source dataset
uspto-grants-2014_12
Patent number
US08916577B2

Reaction notes

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