Methylamine → 5-bromo-N-methylpyrimidine-2-carboxamide

HRID 1406289Notes

Reaction equation

HRID 1406289 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][C:5]([C:8]([O:10]C)=O)=[N:6][CH:7]=1.[CH3:12][NH2:13]>CO.O1CCCC1>[Br:1][C:2]1[CH:7]=[N:6][C:5]([C:8]([NH:13][CH3:12])=[O:10])=[N:4][CH:3]=1

Participants

5

Reactant 2

HCID 6329MethylamineHCID 45790831Methyl 5-bromopyrimidine-2-carboxylate

Product 1

HCID 667599265-bromo-N-methylpyrimidine-2-carboxamide

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

Methyl 5-bromopyrimidine-2-carboxylate (94 mg, 0.43 mmol) was dissolved in a mixture of methanol (1 mL) and tetrahydrofuran (2 mL). An aqueous solution of methylamine (40%, 0.5 mL) was added. The reaction was stirred at room temperature for three days, and was evaporated to dryness in vacuo. The title compound was obtained as a white solid (94 mg).

Workup

  1. customwas evaporated to dryness in vacuo

Sources & evidence

ORD record
ord-b016a2d69e6f4e44bd34f73789cf2dbf
Source dataset
uspto-grants-2014_12
Patent number
US08916593B2

Reaction notes

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