反应详情

A solution of 6.80 g (54.8 mmol) of pyrimidine-5-carboxylic acid, 18.82 mL (135 mmol) of triethylamine and 19.27 g (60 mmol) of TBTU in 200 mL THF was stirred for 30 minutes at ambient temperature. Then 9.11 g (55 mmol) of ethyl 1-amino-cyclopropanecarboxylate hydrochloride were added and the mixture was stirred further overnight. Then the mixture was evaporated down, the residue was stirred with 200 mL water and the crude product was extracted with ethyl acetate. The intermediate product was purified by column chromatography (silica gel, dichloromethane+0-4% methanol).

1. customThen the mixture was evaporated down
2. stirringthe residue was stirred with 200 mL water
3. extractionthe crude product was extracted with ethyl acetate
4. customThe intermediate product was purified by column chromatography (silica gel, dichloromethane+0-4% methanol)