2-Chlorophenol → HCID 86658815, compound

HRID 1406343Notes

Reaction equation

HRID 1406343 reaction equation
[F:1][C:2]1[CH:9]=[C:8](F)[CH:7]=[CH:6][C:3]=1[CH:4]=[O:5].C([O-])([O-])=O.[K+].[K+].[Cl:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[OH:24]>CS(C)=O>[Cl:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[O:24][C:8]1[CH:7]=[CH:6][C:3]([CH:4]=[O:5])=[C:2]([F:1])[CH:9]=1

Participants

5

Reactant 3

HCID 72452-ChlorophenolHCID 11430Potassium CarbonateHCID 737702,4-Difluorobenzaldehyde

Product 1

HCID 86658815HCID 86658815, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent2×

Procedure

142 mg (1 mmol) of 2,4-difluorobenzaldehyde were dissolved in 5 ml DMSO and taken and combined with 200 mg (1.45 mmol) of K2CO3. 128 mg (1 mmol) of 2-chlorophenol were dissolved in 10 ml DMSO and added and stirred for 2 days at ambient temperature. The reaction mixture was filtered through basic Alox, washed with DMF and concentrated by rotary evaporation. The substance was purified by reversed-phase chromatography.

Workup

  1. additionadded
  2. filtrationThe reaction mixture was filtered through basic Alox
  3. washwashed with DMF
  4. concentrationconcentrated by rotary evaporation
  5. customThe substance was purified by reversed-phase chromatography

Sources & evidence

ORD record
ord-08b24ce91153445a80650e3c015f95e8
Source dataset
uspto-grants-2014_12
Patent number
US08916589B2

Reaction notes

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