反应详情

温度

120 °C

A solution of 1.17 g (7.54 mmol) of 2-chloro-4-fluorobenzonitrile and 0.97 g (7.54 mmol) of 2-chlorophenol in 40 mL DMSO was combined with 3.2 g (23.16 mmol) of potassium carbonate and stirred overnight at 120° C. Then the mixture was evaporated to dryness in vacuo, the residue was mixed with water and extracted with ethyl acetate. The extracts were washed with water and saturated sodium chloride solution, dried and evaporated down. The crude product thus obtained was purified by column chromatography (silica gel, dichloromethane).

1. customThen the mixture was evaporated to dryness in vacuo
2. additionthe residue was mixed with water
3. extractionextracted with ethyl acetate
4. washThe extracts were washed with water and saturated sodium chloride solution
5. customdried
6. customevaporated down