Diisopropylethylamine → N-{1-[4-(4-methoxy-2-trifluoromethyl-phenoxy)-benzylcarbamoyl]-cyclopropyl}-malonic acid monoamide monoethylester
Reaction equation
CCN(C(C)C)C(C)C.CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F.[CH2:32]([O:34][C:35](=[O:40])[CH2:36][C:37]([O-:39])=O)[CH3:33].FC(F)(F)C(O)=O.[CH3:48][O:49][C:50]1[CH:70]=[CH:69][C:53]([O:54][C:55]2[CH:68]=[CH:67][C:58]([CH2:59][NH:60][C:61]([C:63]3([NH2:66])[CH2:65][CH2:64]3)=[O:62])=[CH:57][CH:56]=2)=[C:52]([C:71]([F:74])([F:73])[F:72])[CH:51]=1>CN(C=O)C>[CH2:32]([O:34][C:35](=[O:40])[CH2:36][C:37]([NH:66][C:63]1([C:61](=[O:62])[NH:60][CH2:59][C:58]2[CH:57]=[CH:56][C:55]([O:54][C:53]3[CH:69]=[CH:70][C:50]([O:49][CH3:48])=[CH:51][C:52]=3[C:71]([F:73])([F:74])[F:72])=[CH:68][CH:67]=2)[CH2:65][CH2:64]1)=[O:39])[CH3:33]Participants
6
Reactant 4
Product 1
Reagents, catalysts & solvents 1
Procedure
87 μL (0.50 mmol) of DIPEA and 80.9 mg (0.25 mmol) of TBTU were added to a solution of 33.27 mg (0.25 mmol) of monoethylmalonate in 100 μL DMF and the mixture was stirred for 5 min at RT. Then 83 mg (0.17 mmol) of 1-amino-cyclopropanecarboxylic acid 4-(4-methoxy-2-trifluoromethyl-phenoxy)-benzylamide-trifluoroacetic acid salt (from 85a) was added and the mixture was stirred for 1.5 h at ambient temperature. The reaction mixture was purified by chromatography (reversed phase).
Workup
- stirringthe mixture was stirred for 1.5 h at ambient temperature
- customThe reaction mixture was purified by chromatography (reversed phase)
Sources & evidence
- ORD record
- ord-02e8560fd18a488c8436aa343c7c8330
- Source dataset
- uspto-grants-2014_12
- Patent number
- US08916589B2
Reaction notes
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