Hydrochloric Acid → HCID 58487895, compound

HRID 1406383Notes

Reaction equation

HRID 1406383 reaction equation
C[O:2][C:3](=[O:35])[CH2:4][CH2:5][C:6]([NH:8][C:9]1([C:12](=[O:34])[NH:13][CH2:14][C:15]2[CH:20]=[CH:19][C:18]([O:21][C:22]3[CH:27]=[CH:26][C:25]([O:28][CH3:29])=[CH:24][C:23]=3[C:30]([F:33])([F:32])[F:31])=[CH:17][CH:16]=2)[CH2:11][CH2:10]1)=[O:7].[OH-].[Na+].Cl>C1COCC1>[CH3:29][O:28][C:25]1[CH:26]=[CH:27][C:22]([O:21][C:18]2[CH:17]=[CH:16][C:15]([CH2:14][NH:13][C:12]([C:9]3([NH:8][C:6](=[O:7])[CH2:5][CH2:4][C:3]([OH:35])=[O:2])[CH2:11][CH2:10]3)=[O:34])=[CH:20][CH:19]=2)=[C:23]([C:30]([F:31])([F:33])[F:32])[CH:24]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 66792611HCID 66792611, compound

Product 1

HCID 58487895HCID 58487895, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 82 mg (0.166 mmol) of N-{1-[4-(4-methoxy-2-trifluoromethyl-phenoxy)-benzylcarbamoyl]-cyclopropyl}-succinic acid-monoamide-methylester (product from Example 132) and 2 mL sodium hydroxide solution (1 N) in 10 mL THF was stirred for two hours at ambient temperature, then neutralised with 0.1 N hydrochloric acid and evaporated down. The solid residue was stirred in approx. 3 mL dichloromethane, filtered off and evaporated down again.

Workup

  1. customevaporated down
  2. filtrationfiltered off
  3. customevaporated down again

Sources & evidence

ORD record
ord-be169eeabc5b472db9f15a802dd64f2c
Source dataset
uspto-grants-2014_12
Patent number
US08916589B2

Reaction notes

Loading…