2-Fluoro-4-nitrobenzoic acid → 4-Amino-2-fluorobenzoic acid

HRID 1406474Notes

Reaction equation

HRID 1406474 reaction equation

[F:1][C:2]1[CH:10]=[C:9]([N+:11]([O-])=O)[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]>C1COCC1.[Pd]>[NH2:11][C:9]1[CH:8]=[CH:7][C:3]([C:4]([OH:6])=[O:5])=[C:2]([F:1])[CH:10]=1

Participants

4

Reactant 1

HCID 3026792-Fluoro-4-nitrobenzoic acid

Product 1

HCID 3026804-Amino-2-fluorobenzoic acid

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalyst

HCID 8028TetrahydrofuranSolvent

Procedure

Prepared analogously to example 1b by hydrogenation of 2-fluoro-4-nitro-benzoic acid using palladium/charcoal 10% in THF.

Sources & evidence

ORD record: ord-8307f8d12c4e461696f600df3b4746f8
Source dataset: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08916599B2

Reaction notes

Loading…