Hydrochloric Acid → 4-Amino-2-fluoro-5-nitrobenzoic acid

HRID 1406477Notes

Reaction equation

HRID 1406477 reaction equation
C([NH:4][C:5]1[C:13]([N+:14]([O-:16])=[O:15])=[CH:12][C:8]([C:9]([OH:11])=[O:10])=[C:7]([F:17])[CH:6]=1)(=O)C.Cl>O1CCOCC1>[NH2:4][C:5]1[C:13]([N+:14]([O-:16])=[O:15])=[CH:12][C:8]([C:9]([OH:11])=[O:10])=[C:7]([F:17])[CH:6]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 672303024-Acetamido-2-fluoro-5-nitrobenzoic acid

Product 1

HCID 597853374-Amino-2-fluoro-5-nitrobenzoic acid

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Prepared analogously to example 145b from 4-acetylamino-2-fluoro-5-nitro-benzoic acid and half-conc. hydrochloric acid in dioxane.

Sources & evidence

ORD record
ord-3b58e9717b744d12acc4f82c63d1455c
Source dataset
uspto-grants-2014_12
Patent number
US08916599B2

Reaction notes

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