Thionyl Chloride → 4-Amino-5-nitro-2-fluoro-benzoyl chloride

HRID 1406478Notes

Reaction equation

HRID 1406478 reaction equation

[NH2:1][C:2]1[C:10]([N+:11]([O-:13])=[O:12])=[CH:9][C:5]([C:6](O)=[O:7])=[C:4]([F:14])[CH:3]=1.S(Cl)([Cl:17])=O>ClCCCl>[NH2:1][C:2]1[C:10]([N+:11]([O-:13])=[O:12])=[CH:9][C:5]([C:6]([Cl:17])=[O:7])=[C:4]([F:14])[CH:3]=1

Participants

4

Reactant 2

HCID 24386Thionyl Chloride

HCID 597853374-Amino-2-fluoro-5-nitrobenzoic acid

Product 1

HCID 866603804-Amino-5-nitro-2-fluoro-benzoyl chloride

Reagents, catalysts & solvents 1

HCID 111,2-DichloroethaneSolvent

Procedure

Prepared analogously to example 53a from 4-amino-5-nitro-2-fluoro-benzoic acid and thionyl chloride in 1,2-dichloroethane.

Sources & evidence

ORD record: ord-dce61302b2cc40dfb349ecacfd1c3a60
Source dataset: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08916599B2

Reaction notes

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