Ethanol → Ethyl 2,4-difluoro-5-nitrobenzoate

HRID 1406523Notes

Reaction equation

HRID 1406523 reaction equation
[F:1][C:2]1[CH:10]=[C:9]([F:11])[C:8]([N+:12]([O-:14])=[O:13])=[CH:7][C:3]=1[C:4](Cl)=[O:5].[CH2:15]([OH:17])[CH3:16]>C1COCC1>[CH2:15]([O:17][C:4](=[O:5])[C:3]1[CH:7]=[C:8]([N+:12]([O-:14])=[O:13])[C:9]([F:11])=[CH:10][C:2]=1[F:1])[CH3:16]

Participants

4

Reactant 2

HCID 702EthanolHCID 183144972,4-Difluoro-5-nitrobenzoyl chloride

Product 1

HCID 22330120Ethyl 2,4-difluoro-5-nitrobenzoate

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Prepared analogously to example 156a from 2,4-difluoro-5-nitro-benzoyl chloride (5.0 g, 22.6 mmol), ethanol and TEA in THF.

Sources & evidence

ORD record
ord-600e91d12571459f8d69dd80a55d4666
Source dataset
uspto-grants-2014_12
Patent number
US08916599B2

Reaction notes

Loading…