Methylamine → 4-(Methylamino)-3-nitrobenzoic acid

HRID 1406534Notes

Reaction equation

HRID 1406534 reaction equation

F[C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=1[N+:11]([O-:13])=[O:12].[CH3:14][NH2:15]>C1COCC1>[CH3:14][NH:15][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=1[N+:11]([O-:13])=[O:12]

Participants

4

Reactant 2

HCID 6329Methylamine

HCID 679874-Fluoro-3-nitrobenzoic acid

Product 1

HCID 2834754-(Methylamino)-3-nitrobenzoic acid

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Prepared analogously to example 156b from 4-fluoro-3-nitrobenzoic acid and 2 M methylamine (solution in THF) in THF.

Sources & evidence

ORD record: ord-a762f4c599b24bfaa66e90ef96fd8282
Source dataset: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08916599B2

Reaction notes

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