Diisopropylethylamine → HCID 86691677, compound

HRID 1407042Notes

Reaction equation

HRID 1407042 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([NH:11][C:12]3[N:17]=[C:16]([O:18][CH2:19][C:20]([F:23])([F:22])[F:21])[N:15]=[C:14]([NH:24][C:25]4[CH:33]=[CH:32][C:28]([C:29](O)=[O:30])=[C:27]([F:34])[CH:26]=4)[N:13]=3)[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F.[NH2:57][CH2:58][C:59]([CH3:68])([CH3:67])[CH2:60][NH:61][C:62](=[O:66])[C:63]([NH2:65])=[O:64].CCN(C(C)C)C(C)C>CN(C=O)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([NH:11][C:12]3[N:17]=[C:16]([O:18][CH2:19][C:20]([F:22])([F:21])[F:23])[N:15]=[C:14]([NH:24][C:25]4[CH:33]=[CH:32][C:28]([C:29]([NH:57][CH2:58][C:59]([CH3:68])([CH3:67])[CH2:60][NH:61][C:62](=[O:66])[C:63]([NH2:65])=[O:64])=[O:30])=[C:27]([F:34])[CH:26]=4)[N:13]=3)[CH2:10][CH2:9]2)=[CH:4][CH:3]=1

Participants

6

Reactant 4

HCID 81531DiisopropylethylamineHCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 86691678HCID 86691678, compoundHCID 86691679HCID 86691679, compound

Product 1

HCID 86691677HCID 86691677, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a solution of 4-((4-((1-(4-chlorophenyl)cyclopropyl)amino)-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl)amino)-2-fluorobenzoic acid (10 mg) and TBTU (7.74 mg) in DMF (1 mL) was added N1-(3-amino-2,2-dimethylpropyl)oxalamide (4.18 mg) and DIPEA (0.018 mL). The mixture was stirred at room temperature for 2 hours. The product was isolated by using preparative HPLC system.

Workup

  1. customThe product was isolated

Sources & evidence

ORD record
ord-98aa78723f2148d1a2b31575be8f3404
Source dataset
uspto-grants-2014_12
Patent number
US08916702B2

Reaction notes

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