Water → 2-Chloro-4,6-bis(morpholin-4-yl)-1,3,5-triazine

HRID 1408436Notes

Reaction equation

HRID 1408436 reaction equation
[N:1]1[C:8](Cl)=[N:7][C:5](Cl)=[N:4][C:2]=1[Cl:3].[NH:10]1[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1.[OH2:16]>CN(C=O)C>[Cl:3][C:2]1[N:1]=[C:8]([N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)[N:7]=[C:5]([N:10]2[CH2:15][CH2:14][O:16][CH2:12][CH2:11]2)[N:4]=1

Participants

5

Reactant 3

HCID 962WaterHCID 7954Cyanuric chlorideHCID 8083Morpholine

Product 1

HCID 2249672-Chloro-4,6-bis(morpholin-4-yl)-1,3,5-triazineYield 56%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Cyanuric chloride (1.00 g, 5.42 mmol, 1.0 eq.) was dissolved in DMF (5 ml) and morpholine (2.11 ml, 24.4 mmol, 4.5 eq.) was slowly added into reaction mixture at 0° C., stirred for 20 minutes at the same temperature, poured to water and colorless precipitate was filtered, washed with hexane and diethyl ether and dried to provide the title compound as a colorless solid (860 mg, 56%).

Workup

  1. filtrationwas filtered
  2. washwashed with hexane and diethyl ether
  3. customdried

Sources & evidence

ORD record
ord-888efa4c8d3b46dc8ade81d2c2617ab8
Source dataset
uspto-grants-2014_12
Patent number
US08921361B2

Reaction notes

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