Tributyltin azide → HCID 178477295, compound

HRID 1408992Notes

Reaction equation

HRID 1408992 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]2[C:10]([S:11][CH2:12][CH3:13])=[C:9]([C:14]([NH2:16])=[O:15])[CH:8]=[N:7][N:6]2[CH:17]=1)#[N:2].[N:18]([Sn](CCCC)(CCCC)CCCC)=[N+:19]=[N-:20]>CN1C(=O)CCC1>[CH2:12]([S:11][C:10]1[C:5]2[N:6]([CH:17]=[C:3]([C:1]3[NH:20][N:19]=[N:18][N:2]=3)[CH:4]=2)[N:7]=[CH:8][C:9]=1[C:14]([NH2:16])=[O:15])[CH3:13]

Participants

4

Reactant 2

HCID 4984872Tributyltin azideHCID 68291139HCID 68291139, compound

Product 1

HCID 178477295HCID 178477295, compound

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

A solution of 6-cyano-4-(ethylthio)pyrrolo[1,2-b]pyridazine-3-carboxamide (140 mg, 0.568 mmol) and azidotributyltin (0.187 mL, 0.682 mmol) in NMP (2.0 mL) was heated to 180° C. for 60 minutes under microwave oven (CEM). The reaction mixture was taken to the next step without purification. MS (ES+) m/z: 290.08 (M+H).

Workup

  1. customThe reaction mixture was taken to the next step without purification

Sources & evidence

ORD record
ord-fd479cdc7e4c43238816e66c6a74d1d2
Source dataset
uspto-grants-2014_12
Patent number
US08921368B2

Reaction notes

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