1,2-Dichloroethane → HCID 67133145, compound

HRID 1409119Notes

Reaction equation

HRID 1409119 reaction equation
FC1N=C(C2C=[CH:12][N:11]=[C:10]3[N:14](S(C4C=CC(C)=CC=4)(=O)=O)[CH:15]=[CH:16][C:9]=23)C=CC=1.[CH2:27]([Cl:30])[CH2:28]Cl.[CH:31]1[CH:32]=C[C:34]2[N:39](O)N=[N:37][C:35]=2[CH:36]=1.CN(C=[O:45])C>>[Cl:30][C:27]1[C:28]([C:31]2[CH:36]=[C:35]([C:34]([NH2:39])=[O:45])[NH:37][CH:32]=2)=[C:9]2[CH:16]=[CH:15][NH:14][C:10]2=[N:11][CH:12]=1

Participants

5

Reactant 4

HCID 111,2-DichloroethaneHCID 6228DimethylformamideHCID 757711-HydroxybenzotriazoleHCID 58896987HCID 58896987, compound

Product 1

HCID 67133145HCID 67133145, compound

Procedure

To a vial with Compound J′ (0.1 mmol) in DMF (1 mL), EDC (2 equivalent, 0.2 mmol) and HOBt (0.5 equivalent, 0.05 mmol) were added and the reaction mixture was stirred at room temperature for half an hour, amine (1.2 equivalent, 0.12 mmol) was added and the reaction mixture was stirred at room temperature for 2-3 hour. Reverse phase HPLC was used to purify the final compound.

Workup

  1. stirringthe reaction mixture was stirred at room temperature for 2-3 hour
  2. customto purify the final compound

Sources & evidence

ORD record
ord-74cb6d6f2f7b4fffa53e5338365d03ab
Source dataset
uspto-grants-2014_12
Patent number
US08921376B2

Reaction notes

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