反应详情

(R)-Ethyl 1-(2-hydroxypropyl)-2-methyl-1H-imidazole-4-carboxylate (2.474 mmol, 525 mg) was dissolved in methanol (1 ml) and THF (8 ml). NaOH 2 M (7.42 mmol, 3.71 ml) was added and the resulting mixture was stirred overnight at RT. The pH of the mixture was adjusted to about 5 with 1M HCl and the solvents were evaporated. Ethanol was added and the salts were removed by filtration. The filtrate was evaporated. 393 mg of the title compound was obtained. 1H-NMR (400 MHz, DMSO-d6): δ 1.03 (m, 6H), 2.30 (s, 3H), 3.71-3.80 (m, 1H), 3.81-3.97 (m, 2H), 4.95 (bs), 7.67 (s, 1H).

1. customthe solvents were evaporated
2. additionEthanol was added
3. customthe salts were removed by filtration
4. customThe filtrate was evaporated