反应详情

温度

60 °C

Ethyl 2-methyl-1H-imidazole-4-carboxylate (1.622 mmol, 250 mg) and potassium carbonate (16.22 mmol, 2241 mg) were dissolved in dry DMF (5 ml) under nitrogen atmosphere. (S)-2-methyloxirane (24.32 mmol, 1.723 ml) was added and the resulting mixture was heated to 60° C. and stirred for 5.5 h. More (S)-2-methyloxirane (1 ml) was added and the stirring continued at 60° C. for one additional hour. The solvent was evaporated. The crude product was purified by flash chromatography. 139 mg of the title compound was obtained. 1H-NMR (400 MHz, DMSO-d6): δ 1.06 (d, 3H), 1.24 (t, 3H), 2.30 (s, 3H), 3.71-3.89 (m, 4H), 4.18 (q, 2H), 7.73 (s, 1H).

1. customcontinued at 60° C. for one additional hour
2. customThe solvent was evaporated
3. customThe crude product was purified by flash chromatography