Malonic Acid → 3-Methyl-2-nitropyridine

HRID 140937Notes

Reaction equation

HRID 140937 reaction equation
[C:21]([O:22][CH2:23][CH3:24])(=[O:25])[CH2:26][C:27]([O:28][CH2:29][CH3:30])=[O:31].[C:32]([O:33][CH3:34])(=[O:35])[CH2:36][C:37]([O:38][CH3:39])=[O:40].[Cl:1][c:2]1[c:3]([N+:8](=[O:9])[O-:10])[n:4][cH:5][cH:6][cH:7]1.[K:19].[Li:20].[Na:18].[OH:11][C:12]([CH2:13][C:14](=[O:15])[OH:16])=[O:17]>>[c:2]1([CH3:12])[c:3]([N+:8](=[O:9])[O-:10])[n:4][cH:5][cH:6][cH:7]1

Participants

8

Reactant 7

HCID 867Malonic AcidHCID 7761Diethyl MalonateHCID 7943Dimethyl malonateHCID 5549883-Chloro-2-nitropyridineHCID 3028194LithiumHCID 5360545SodiumHCID 5462222Potassium

Product 1

HCID 5642053-Methyl-2-nitropyridine

Sources & evidence

ORD record
ord-eebfd7ed98ae4e16a57413dd59c2b69c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

Loading…