Acetate → Ethyl 3-(3,4-difluoro-5-hydroxyphenyl)prop-2-enoate

HRID 140943Notes

Reaction equation

HRID 140943 reaction equation
[Br:1][c:2]1[cH:3][c:4]([F:10])[c:5]([F:9])[c:6]([OH:8])[cH:7]1.[C:11]([CH:12]=[CH2:13])(=[O:14])[O:15][CH2:16][CH3:17].[C:36](#[N:37])[CH2:38][CH3:39].[CH:18]([N:19]([CH:20]([CH3:21])[CH3:22])[CH2:23][CH3:24])([CH3:25])[CH3:26].[O-:28][C:29]([CH3:30])=[O:31].[O-:32][C:33]([CH3:34])=[O:35].[Pd+2:27]>>[c:2]1([CH:13]=[CH:12][C:11](=[O:14])[O:15][CH2:16][CH3:17])[cH:3][c:4]([F:10])[c:5]([F:9])[c:6]([OH:8])[cH:7]1

Participants

7

Reactant 6

HCID 175Acetate2×HCID 7854PropionitrileHCID 8821Ethyl AcrylateHCID 81531DiisopropylethylamineHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 27733075-Bromo-2,3-Difluorophenol

Product 1

HCID 76548871Ethyl 3-(3,4-difluoro-5-hydroxyphenyl)prop-2-enoate

Sources & evidence

ORD record
ord-a787b35b747442ea8b9303a835fb9962
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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