Trifluoroacetic acid → HCID 56654141, compound

HRID 1409513Notes

Reaction equation

HRID 1409513 reaction equation
FC(F)(F)C(O)=O.Cl[C:9]1[N:14]=[C:13]([F:15])[C:12]2[O:16][C:17]3[C:22]([C@@:23]4([C:27]5[CH:28]=[N:29][CH:30]=[CH:31][C:26]=5[C:25]([NH2:32])=[N:24]4)[C:11]=2[CH:10]=1)=[CH:21][C:20]([C:33]1[C:34]([F:39])=[N:35][CH:36]=[CH:37][CH:38]=1)=[CH:19][CH:18]=3.[O:40]1[CH2:45][CH2:44][CH:43]=[C:42](B2OC(C)(C)C(C)(C)O2)[CH2:41]1.C(O)(C(F)(F)F)=O>>[O:40]1[CH2:45][CH2:44][CH:43]=[C:42]([C:9]2[N:14]=[C:13]([F:15])[C:12]3[O:16][C:17]4[C:22]([C@@:23]5([C:27]6[CH:28]=[N:29][CH:30]=[CH:31][C:26]=6[C:25]([NH2:32])=[N:24]5)[C:11]=3[CH:10]=2)=[CH:21][C:20]([C:33]2[C:34]([F:39])=[N:35][CH:36]=[CH:37][CH:38]=2)=[CH:19][CH:18]=4)[CH2:41]1

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 158366332-(5,6-dihydro-2H-pyran-3-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolaneHCID 86689250HCID 86689250, compound

Product 1

HCID 56654141HCID 56654141, compound

Procedure

The title compound was synthesized by procedures and steps analogous to those described in Example 14 above, but using (S)-3-Chloro-1-fluoro-7-(2-fluoropyridin-3-yl)spiro[chromeno[2,3-c]pyridine-5,3′-pyrrolo[3,4-c]pyridin]-1′-amine 2,2,2-trifluoroacetate (14d-2) and 2-(5,6-dihydro-2H-pyran-3-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane in step 5. MS m/z=496.0 [M+H]+. Calculated for: C28H19F2N5O2.O2HF3O2: 609.50 (TFA salt)

Sources & evidence

ORD record
ord-6a87ed62172348fe811943f0fbd5fd2c
Source dataset
uspto-grants-2014_12
Patent number
US08921363B2

Reaction notes

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