反应详情

温度

140 °C

To a mixture of methyl 2-amino-5-(benzyloxy)-1-methyl-6-oxo-1,6-dihydropyrimidine-4-carboxylate (0.907 g, 3.14 mmol, Eq: 1.00), methylamine 2M in THF (12 ml, 24.0 mmol) was added. The mixture was heated in a microwave oven at 140° C. for 2 h. The crude reaction mixture was concentrated in vacuo to give the title product as an off-white solid (0.90 g; 100%). LCMS: m/z=289 (MH+).

1. additionwas added
2. customThe crude reaction mixture
3. concentrationwas concentrated in vacuo