Lithium Hydroxide → HCID 71093780, compound

HRID 1409706Notes

Reaction equation

HRID 1409706 reaction equation
C([O:3][C:4]([C:6]1[N:10]=[C:9]([C:11]2[CH:16]=[CH:15][C:14]([C:17]#[N:18])=[CH:13][C:12]=2[F:19])[O:8][N:7]=1)=[O:5])C.[Li+].[OH-]>O1CCCC1>[C:17]([C:14]1[CH:15]=[CH:16][C:11]([C:9]2[O:8][N:7]=[C:6]([C:4]([OH:5])=[O:3])[N:10]=2)=[C:12]([F:19])[CH:13]=1)#[N:18]

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 71093740HCID 71093740, compound

Product 1

HCID 71093780HCID 71093780, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The title compound is prepared from 5-(4-cyano-2-fluoro-phenyl)-[1,2,4]oxadiazole-3-carboxylic acid ethyl ester by treatment with aqueous LiOH solution in tetrahydrofuran. LC (method 15): tR=0.69 min; Mass spectrum (ESI+): m/z=234 [M+H]+.

Sources & evidence

ORD record
ord-763f4122caee4f399fd63f9b872ac1e5
Source dataset
uspto-grants-2014_12
Patent number
US08921398B2

Reaction notes

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