反应详情

A mixture of 3-(4-cyano-2-fluoro-phenyl)-5-methoxy-4,5-dihydro-isoxazole-5-carboxylic acid methyl ester (172 mg), 1N aqueous NaOH solution (2 mL), and tetrahydrofuran (5 mL) is stirred at room temperature for 3 h. The reaction mixture is acidified with 1 N hydrochloric acid (approximately pH 3) and concentrated in vacuo. The residue is triturated with water and the precipitate is filtered off and dried to give the title compound. LC (method 18): tR=0.38 min; Mass spectrum (ESI−): m/z=231 [M−H]−.

1. concentrationconcentrated in vacuo
2. customThe residue is triturated with water
3. filtrationthe precipitate is filtered off
4. customdried