Potassium Carbonate → HCID 64265966, compound

HRID 1409725Notes

Reaction equation

HRID 1409725 reaction equation
Cl[C:2]1[N:3]=[CH:4][C:5]([C:8]([O:10]C)=[O:9])=[N:6][CH:7]=1.C([O-])([O-])=O.[K+].[K+].[CH3:18][C:19]1[NH:20][CH:21]=[CH:22][N:23]=1>CN(C)C=O>[CH3:18][C:19]1[N:20]([C:2]2[N:3]=[CH:4][C:5]([C:8]([OH:10])=[O:9])=[N:6][CH:7]=2)[CH:21]=[CH:22][N:23]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 127492-MethylimidazoleHCID 406081Methyl 5-chloropyrazine-2-carboxylate

Product 1

HCID 64265966HCID 64265966, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
100 °C

Procedure

A mixture of methyl 5-chloropyrazine-2-carboxylate (0.75 g), K2CO3 (1.8 g) and 2-methyl-1H-imidazole (1.3 g) in N,N-dimethylformamide (6 mL) is heated to 100° C. overnight. Analysis of the crude mixture by LCMS shows saponified product. The solvents are evaporated and the crude product is purified by HPLC. LC (method 20): tR=0.27 min; Mass spectrum (APCI): m/z=205 [M+H]+.

Workup

  1. customThe solvents are evaporated
  2. customthe crude product is purified by HPLC

Sources & evidence

ORD record
ord-8eb4dc496c91435793f3dc1d3fcdf009
Source dataset
uspto-grants-2014_12
Patent number
US08921398B2

Reaction notes

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